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A departing Republican senator. Would-be replacements lining up in the Trump lane. The party has changed in the last decade and Democrats are positioning themselves to try to win the seat.

When a brewery worker went to Instagram to complain about sexual harassment in her workplace, thousands of other women – and a few men – chimed in with their stories.

NPR's Eric Weiner reports that hundreds, maybe thousands, of people were killed in East Timor in recent weeks because of the rampages of Indonesian army organized militias. But whether the culprits are brought to justice or not is another matter. The United Nations Human Rights commission has voted to establish an international inquiry for East Timor, but Indonesian officials have rejected it.

NPR's David Kestenbaum reports on the first known death in a study of gene implantation. An 18-year-old Arizona man with a rare metabolic disease died in mid-September after undergoing the experimental therapy at the University of Pennsylvania. Experts say the fatality could force changes in the way these experiments are performed and may slow down the advance of so-called "gene-therapy."

General Motors has reached a settlement in a lawsuit resulting from a 1997 car accident. In the crash, a Chevrolet Chevette was struck by another vehicle, and burst into flames, killing the driver. The motorist's widow sued GM. The number-one automaker was sharply criticized by the judge in the case for its efforts to keep two key documents out of the proceedings. The documents date back to 1973 and 1981 and both relate of the potential cost of lawsuits from collisions where a gas-tank fire erupted. Robert speaks with NPR's Don Gonyea about the case.

Linda talks to Nadine Selden of the International Federation of the Red Cross and Red Crescent Societies from her office in Istanbul. Selden says relief efforts are still underway for people effected by the earthquake in Turkey six weeks ago. The most recent aftershock was this morning. Selden says that ten-thousand winterized tents are being prepared for people who have no permanent housing.

John Lurie is a saxophone player, actor, the voice of Molson on Ice, and star of his own fishing program. His band the Lounge Lizards turns 20 this year, and Lurie has released three new music projects. All Things Considered Director Bob Boilen has a profile of this offbeat big band leader. (7:00) CD's heard in this piece are the Lounge Lizards "Queen of All Ears" and the score to Manni and Lo and African Swim, by John Lurie, all the cd's are on the label Strange and Beautiful Music

On the government's fiscal calendar the new year begins Friday, and NPR Senior News Analyst Daniel Schorr says that it's not going to be a holiday.

Linda speaks with former New Jersey Senator Bill Bradley, who is competing with Vice President Gore for the Democratic Party's nomination for President. He joins us from Los Angeles.

NPR's Ailsa Chang speaks with Republican Gov. Spencer Cox of Utah, who is pushing back on anti-vaccine rhetoric but says mandating COVID-19 vaccination and mask-wearing is against state law.